ArticleGeroScience2026
Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss.Frontiers in molecular neuroscience · 2026Review
- Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.Cyborg and bionic systems (Washington, D.C.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related hearing loss (ARHL) is a prevalent condition among older adults and is regarded as a potentially modifiable risk factor for dementia. Although multiple studies have investigated pure-tone thresholds as a measure for ARHL and its relationship to dementia, the potential role of the central auditory system has received little attention. To address this gap in the literature, this study investigates the relationship between central auditory functioning, assessed using the speech-reception-threshold (SRT) of the digits-in-noise (DIN) test, and the microstructural integrity of white matter tracts in the Rotterdam Study. A total of 1669 participants underwent the DIN test and had diffusion imaging data available. The SRT was found to be significantly associated with the microstructural integrity of the left inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and posterior thalamic radiation. After accounting for audibility effects, the association with the inferior fronto-occipital fasciculus and the inferior longitudinal fasciculus was even stronger, while the association with the posterior thalamic radiation was no longer significant. These findings suggest that age-related declines in specific brain regions may contribute to difficulties in speech-in-noise understanding among the elderly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.