ArticleBioresources and bioprocessing2025
Supercritical carbon dioxide extraction of astaxanthin from Corynebacterium glutamicum.
Article in Bioresources and bioprocessing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Extraction of astaxanthin from fresh Haematococcus pluvialis biomass: a sustainable approach using vegetable oils.Archives of microbiology · 2026Article
- Superior Intracellular Antioxidant Activity of an Astaxanthin-Containing Corynebacterial Extract.International journal of molecular sciences · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Astaxanthin, a red carotenoid with potent antioxidant properties, holds significant value in the feed, cosmetics, and nutraceutical industries. While traditionally sourced from microalgae, Corynebacterium glutamicum, a well-established industrial microorganism, has been engineered to serve as an efficient host for astaxanthin production. As astaxanthin integrates into the cellular membrane, effective extraction methods are essential to access this valuable compound. In this study, a sustainable batch extraction process using supercritical carbon dioxide (scCO₂) as a green solvent was developed. The effects of cosolvent concentration (0-9% (w/w)), temperature (50-75 °C), and pressure (450-650 bar) were investigated with regard to the extraction yield. An optimized extraction was achieved with 9% (w/w) ethanol as a cosolvent, at 68 °C and 550 bar, allowing the extraction of 67.5 ± 3.7% of the cellular astaxanthin within 0.5 h. Prolonging the extraction time further increased the recovery to 93.3%, which is comparable to processes that have been established for the extraction of astaxanthin from microalgae and yeast. This approach provides a scalable and environmentally friendly solution for industrial astaxanthin recovery.
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