ArticleJapanese journal of ophthalmology2025
Evaluation of factors relating to the development of multiple subepithelial corneal infiltrates of adenoviral keratoconjunctivitis using categorical data analysis program.
Article in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Genotyping and Clinical Manifestations of Adenoviral Keratoconjunctivitis in South Korea.Korean journal of ophthalmology : KJO · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
purposeAdenoviral keratoconjunctivitis is the most common infectious disease in ophthalmology. Its clinical forms include epidemic keratoconjunctivitis (EKC) and pharyngoconjunctival fever (PCF). EKC can be complicated by multiple subepithelial infiltrates (MSI) of the cornea, which affect visual outcomes. As at present, artificial intelligence and machine learning are becoming increasingly important not only in the diagnostic imaging field but also in the clinical data science field, we investigated a predictive model for the development of corneal MSI in adenoviral keratoconjunctivitis. STUDY
designRetrospective cohort study.
methodsOne hundred and forty cases of adenovirus keratoconjunctivitis diagnosed at Hinokuma Eye Clinic were enrolled. The dependent variable was corneal MSI, and the independent variables were adenovirus genotype, bilaterality, subconjunctival hemorrhage, eyelid swelling, conjunctival edema, conjunctival opacity, pseudomembrane, corneal epithelial findings, preauricular lymphadenopathy, eye discharge, lacrimation, eye pain, foreign body sensation, and itchy eye, which were analyzed by a categorical data analysis program (CATDAP).
resultsFor single independent variables, corneal epithelial findings (Akaike information criterion, AIC=-6.46) and type 54 (AIC=-4.30) showed high predictive performance. In the combination of multiple independent variables, Type 56 or Type 37 with corneal epithelial damage also showed high predictive performance.
conclusionPredicting the occurrence of corneal MSI has until now been considered difficult. When a patient with EKC has marginal corneal epithelial or subepithelial opacities at initial presentation, it is presumed that the patient has a relatively high risk of developing MSI. Knowing the prevalent virus type in advance, would prove helpful in the diagnosis.
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