ArticleMethods in molecular biology (Clifton, N.J.)2025
Ribo-ITP: A Method for Ribosome Profiling in Single Cells and Low-Input Samples.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Allele-specific expression is associated with lower translational efficiency in mouse embryos and stem cells.bioRxiv : the preprint server for biology · 2026Article
- Ribo-ITP enables identification of translons from limited input samples.Nature communications · 2026Article
- Topological and functional characterization of human translation efficiency covariation network.Bioinformatics (Oxford, England) · 2025Article
- Landscape and regulation of mRNA translation in the early C. elegans embryo.Cell reports · 2025Article
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3 authors.
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Abstract
Transcriptome-wide translation can be measured using ribosome profiling, a technique which relies on deep sequencing of ribosome protected fragments. This method enables comprehensive measurement of in vivo translation; however, it involves multiple steps and thereby demands high-input samples. Here, we describe Ribo-ITP (RIBOsome profiling via IsoTachoPhoresis), which utilizes the principles of isotachophoresis coupled with a stringent size selection strategy in a microfluidic chip to isolate ribosome-protected fragments. Ribo-ITP allows quantitative measurement of translation from rare populations like cancer stem cells, early embryonic stages, and other ultralow input samples including single cells.
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