Evidence map›Paper›PMID 40418372›Full record

ArticleBiogerontology2025

Bidirectional upregulation of Klotho by triiodothyronine and baicalein: mitigating chronic kidney disease and associated complications in aged BALB/c mice.

Saswat Kumar Mohanty, Vikas Kumar Sahu, Bhanu Pratap Singh, Kitlangki Suchiang

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Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Saswat Kumar MohantyDepartment of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605 014, India. mohantysk7.5@pondiuni.ac.in.ORCID 0000-0002-6155-3894
Vikas Kumar SahuDepartment of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605 014, India.
Bhanu Pratap SinghDepartment of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605 014, India.
Kitlangki SuchiangDepartment of Biochemistry, North Eastern Hill University, Shillong, 793022, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a global health challenge marked by progressive renal decline and increased mortality. The interplay between CKD and hypothyroidism, particularly nonthyroidal low-triiodothyronine (T3) syndrome, exacerbates disease progression, driven by HPT axis dysfunction and reduced Klotho levels due to the Wnt/β-catenin pathway activation. This study explored Klotho as a link between CKD and hypothyroidism using an adenine-induced CKD aged mouse model. Exogenous T3 and baicalein (BAI), targeting the Wnt pathway, were used to upregulate Klotho expression. Combined T3 and BAI treatment significantly increased Klotho levels, surpassing individual effects, and suppressed key signaling molecules (TGF, NFκB, GSK3), mitigating renal fibrosis and CKD complications, including cardiovascular disorders and dyslipidemia. This bidirectional approach, enhancing Klotho via T3 and sustained Wnt pathway inhibition, offers a novel and effective strategy for CKD management, particularly in elderly patients with hypothyroidism.

Indexed as

FlavanonesGlucuronidaseHypothyroidismRenal Insufficiency, ChronicTriiodothyronineAgingAnimalsDisease Models, AnimalKidneyKlotho ProteinsMaleMiceMice, Inbred BALB CUp-RegulationWnt Signaling PathwaybaicaleinFlavanonesGlucuronidaseKlotho ProteinsTriiodothyronineAgingBaicaleinChronic kidney diseaseKlothoTriiodothyronineWnt/β-catenin

Identifiers

PMID40418372

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.