Evidence map›Paper›PMID 40418320›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Hepatoprotective effect of diosmetin against thioacetamide-induced liver injury via modulating Bax/NF-κB/caspase-3/Nrf-2/PPAR

Radha Goel, Rosaline Mishra, Nitin Kumar, Nungsangtula Imsong, Neelam Singh, Praveen Gaur, Mohd Nazam Ansari, Hassan A Madkhali

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Radha GoelDepartment of Pharmacology, Lloyd Institute of Management & Technology, Plot No.-11, Knowledge Park-II, Greater Noida, Uttar Pradesh, 201306, India. radha.goel@lloydpharmacy.edu.in.ORCID http://orcid.org/0000-0001-6658-5994
Rosaline MishraDepartment of Pharmacy, Metro College of Health Sciences and Research, Plot No- 41, Knowledge Park-III, Uttar Pradesh, 201306, Noida, India.ORCID http://orcid.org/0000-0001-5611-8831
Nitin KumarDepartment of Pharmacy, Meerut Institute of Technology, Meerut, India.ORCID http://orcid.org/0000-0003-4473-6418
Nungsangtula ImsongDepartment of Pharmacology, Lloyd Institute of Management & Technology, Plot No.-11, Knowledge Park-II, Greater Noida, Uttar Pradesh, 201306, India.
Neelam SinghHR Institute of Pharmacy, HRIT University, 8th Km Stone, Delhi-Meerut Road, Ghaziabad, 201003, India.ORCID http://orcid.org/0000-0002-3029-9053
Praveen GaurDepartment of Pharmacy, Metro College of Health Sciences and Research, Plot No- 41, Knowledge Park-III, Uttar Pradesh, 201306, Noida, India.
Mohd Nazam AnsariDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.ORCID http://orcid.org/0000-0001-8580-3002
Hassan A MadkhaliDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.ORCID http://orcid.org/0000-0002-0267-4194

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thioacetamide (TAA), an established liver toxic chemical, is used to develop experimental models of liver injury by inducing inflammation, oxidative stress, and apoptosis. The current study investigates the hepatoprotective effect of diosmetin (DSM), a bioflavonoid molecule, with mechanistic investigations using an in vivo TAA-induced liver injury model because there is no precedence. In the current investigation, 30 Wistar rats were randomly assigned to five groups. The rats were given TAA (200 mg/kg) and DSM (50 and 100 mg/kg body weight) for 8 weeks. Liver function biomarkers (ALT, ASP, AST, bilirubin, GGT, CRP, albumin, globulin, and total protein) and inflammatory markers were analyzed on serum, whereas antioxidant levels, histological evaluation, and apoptotic markers were evaluated on liver tissue. The finding of this study indicated that DSM ameliorates TAA-induced increases in ALT, ASP, AST, bilirubin, GGT, CRP, MDA, albumin, globulin, total protein, and antioxidant enzyme activity such as SOD, CAT, and GSH levels. DSM reduced alterations in inflammatory biomarkers (IL-6, IL-1β, TNF-α) and apoptotic markers (Bax, NF-κB, caspase-3, Nrf-2, PPAR

Indexed as

Chemical and Drug Induced Liver InjuryFlavonoidsProtective AgentsAnimalsAntioxidantsApoptosisbcl-2-Associated X ProteinCaspase 3LiverMaleNF-E2-Related Factor 2NF-kappa BOxidative StressPPAR gammaRatsRats, WistarAntioxidantsBax protein, ratbcl-2-Associated X ProteinCasp3 protein, ratCaspase 3diosmetinFlavonoidsNfe2l2 protein, ratNF-E2-Related Factor 2NF-kappa BPPAR gammaPPAR gamma, ratProtective AgentsThioacetamideApoptosisDiosmetinHepatotoxicityInflammatory biomarkerThioacetamide

Identifiers

PMID40418320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.