Evidence map›Paper›PMID 40418024›Full record

ArticleAnalytical chemistry2025

Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma.

Youngjae Kim, Ting Ting Zhang, Hiroshi Sugimoto, Mark G Qian, Linlin Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Youngjae KimDepartment of Drug Metabolism and Pharmacokinetics, and Modeling, Takeda Development Center Americas, Incorporation, 35 Landsdowne Street, Cambridge, Massachusetts 02139, United States.ORCID 0009-0009-3164-6940
Ting Ting ZhangDepartment of Drug Metabolism and Pharmacokinetics, and Modeling, Takeda Development Center Americas, Incorporation, 35 Landsdowne Street, Cambridge, Massachusetts 02139, United States.
Hiroshi SugimotoDepartment of Drug Metabolism and Pharmacokinetics, and Modeling, Takeda Development Center Americas, Incorporation, 35 Landsdowne Street, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-3846-2302
Mark G QianDepartment of Drug Metabolism and Pharmacokinetics, and Modeling, Takeda Development Center Americas, Incorporation, 35 Landsdowne Street, Cambridge, Massachusetts 02139, United States.
Linlin DongDepartment of Drug Metabolism and Pharmacokinetics, and Modeling, Takeda Development Center Americas, Incorporation, 35 Landsdowne Street, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-7944-8582

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid chromatography-mass spectrometry (LC/MS) plays a crucial role in the quantification of small interfering RNAs (siRNAs) in biological matrices. However, the recovery of siRNA from complex biological matrices remains a significant challenge. Focusing on liver-targeted

Indexed as

AcetylgalactosamineBlood ProteinsRNA, Small InterferingAnimalsChemical PrecipitationChromatography, LiquidHumansRatsSolid Phase ExtractionTandem Mass SpectrometryWorkflowAcetylgalactosamineBlood ProteinsRNA, Small Interfering

Identifiers

PMID40418024
PMCPMC12163879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.