Evidence map›Paper›PMID 40417854›Full record

ReviewMagnetic resonance in chemistry : MRC2025

Quantitative Solid-State NMR Spectroscopy (qSSNMR) in Pharmaceutical Analysis.

Zhaoxi Zheng, Kang Chen, Yang Liu, Eric J Munson, Yongchao Su

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Magnetic resonance in chemistry : MRC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhaoxi ZhengDepartment of Chemistry, Brandeis University, Waltham, Massachusetts, USA.ORCID 0009-0006-3867-8409
Kang ChenDivision of Pharmaceutical Quality Research II, Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0003-0276-2474
Yang LiuScience General Chapters, US Pharmacopeial Convention, Rockville, Maryland, USA.ORCID 0000-0002-8064-7108
Eric J MunsonDepartment of Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, Indiana, USA.
Yongchao SuPharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., Rahway, New Jersey, USA.ORCID 0000-0001-5063-3218

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Pharmaceutical analysis is essential to drug development and quality assurance, ensuring that products meet stringent safety and efficacy standards. Quantitative solid-state NMR (qSSNMR) has become a key technique, enabling precise quantification and characterization of solid drug formulations. This mini-review highlights the evolution of qSSNMR, focusing on improvements in detection limits, resolution, and high-throughput capabilities. This review explores technical advancements and applications for analyzing complex pharmaceutical mixtures. While challenges remain for widespread adoption, efforts in automation, user-friendly software, and collaboration aim to address these.

Indexed as

Magnetic Resonance SpectroscopyPharmaceutical PreparationsPharmaceutical Preparationscomplex drug formulationspharmaceutical analysisqSSNMRquantitative solid‐state NMRsolid‐state characterization

Identifiers

PMID40417854
PMCPMC12379110

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.