Evidence map›Paper›PMID 40417805›Full record

ArticleThe Laryngoscope2025

Factors Affecting Nasal Discharge in Chronic Rhinosinusitis Patients.

Pranav A Patel, Ethan M Kallenberger, Shaun A Nguyen, Jess C Mace, Alexander N Duffy, Zachary M Soler, Timothy L Smith, Rodney J Schlosser

2 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01332136 completednot on this map

Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis

TypeobservationalSponsorOregon Health and Science UniversityRan2011 to 2016Enrolled966ConditionsChronic Rhinosinusitis
NCT02720653 unknown statusnot on this map

Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis

TypeobservationalSponsorOregon Health and Science UniversityRan2016 to 2022Enrolled418ConditionsChronic Rhinosinusitis, Olfactory DysfunctionArmsEndoscopic sinus surgery
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pranav A PatelDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0009-0000-0627-5142
Ethan M KallenbergerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0009-0007-8196-5603
Shaun A NguyenDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-0664-4571
Jess C MaceDepartment of Otolaryngology - Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Alexander N DuffyDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-4304-595X
Timothy L SmithDepartment of Otolaryngology - Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-6424-7083
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

DETERMINANTS OF SURGICAL OUTCOMES IN CHRONIC SINUSITISR01DC005805 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SMITH, TIMOTHY L, SOLER, ZACHARY M · 2004 to 2020
$7.6M
NIDCD NIH HHS R01 DC005805
6 · The paper itself

Abstract

backgroundNasal discharge is a cardinal symptom of chronic rhinosinusitis (CRS); however, patients often use variable descriptions for this symptom. The 22-item Sinonasal Outcomes Test (SNOT-22) presents four different questions regarding this symptom. The objective of this cross-sectional analysis was to determine which patient-specific factors influence the severity of nasal drainage. METHODOLOGY: Demographic information, medical history, and SNOT-22 scores were recorded at baseline as part of a multi-institutional, prospective cohort study of patients with CRS refractory to medical therapy. Severe symptoms were defined as scores ≥ 3 on the SNOT-22 item response. Bivariate odds ratio (OR) calculations and multivariate regression analysis were completed.

resultsA total of 1020 patients were included, equally split based on gender and polyp status. On the SNOT-22, postnasal discharge (PND) was the most severe discharge symptom reported, with an average score of 2.98 [SD ± 1.5] and 67.3% of patients reporting severe disease. Female sex (OR = 2.0, [95% CI: 1.5-2.5]), diagnosis of CRS without nasal polyps (OR = 1.5, [95% CI: 1.1-2.0]), prior endoscopic sinus surgery (ESS) (OR = 1.5, [95% CI: 1.1-2.0]), and allergies (OR = 1.4, [95% CI: 1.1-1.8]) were significantly associated with severe PND, while comorbid acid reflux was not (OR = 1.1, [95% CI: 0.8-1.6]; p = 0.53).

conclusionOf the various forms of nasal discharge, patients with CRS report worse symptoms related to PND. This is the first study to evaluate the effects of demographic and comorbid conditions on the presentation and severity of PND. Female sex, CRSsNP, prior ESS, and comorbid allergies are associated with higher odds of having severe PND. LEVEL OF EVIDENCE: 3 Trial Registration: www. CLINICALTRIALS: gov: NCT02720653 and NCT01332136.

Indexed as

RhinitisSinusitisAdultAgedChronic DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedNasal PolypsProspective StudiesRhinosinusitisSeverity of Illness IndexSex FactorsSino-Nasal Outcome Testchronic rhinosinusitisnasal mucosaparanasal sinusespost‐nasal drainage

Identifiers

PMID40417805
PMCPMC12645348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.