Observational studyJournal of the American Heart Association2025
Impact of Left Ventricular Diastolic Pressure Changes on Clinical Outcomes After Transcatheter Aortic Valve Replacement.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Early Enhancement of Mitral Annular e' Following Transcatheter Aortic Valve Implantation: The Role of Early Diastolic Filling.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Integrated Impact of Post-TAVR Cardiac Damage and Pacemaker Implantation on Long-Term Outcomes.Biomedicines · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in left ventricular (LV) diastolic pressure after transcatheter aortic valve replacement (TAVR) or their relationship with subsequent outcomes remain poorly clarified. Accordingly, we aimed to assess the changes in invasively measured LV diastolic pressure and their relationship with long-term outcomes in patients undergoing TAVR.
methodsIn total, 509 patients with severe aortic stenosis who underwent TAVR at 3 tertiary centers were retrospectively included and divided into 2 groups according to changes in LV pre-A pressure after TAVR: Group 1, with no change or decrease in pre-A pressure, and Group 2, presenting an increase in pre-A pressure after TAVR. The primary outcome was a composite of all-cause death and rehospitalization for heart failure.
resultsGroup 1 included 39% (n=198) patients, and Group 2 had 61% (n=311) patients. More patients in Group 2 had diabetes, chronic kidney disease, and a larger aortic valve area than in Group 1. During the follow-up period (median, 28 months), 122 primary outcomes were recorded. In Kaplan-Meier analysis, the cumulative incidence of the primary outcome and all-cause death was significantly lower in Group 1 than in Group 2. In multivariable Cox hazard models, Group 1 was independently associated with a favorable primary outcome (hazard ratio, 0.52 [95% CI, 0.34-0.80];
conclusionsIncrease in LV pre-A pressure after TAVR is common, and no change or decrease in LV pre-A pressure after TAVR is independently associated with favorable outcomes. Changes in LV pre-A pressure can help identify patient subsets who will maximally benefit from TAVR.
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