ArticleHemodialysis international. International Symposium on Home Hemodialysis2025
Relationship Between Periodontitis and Nitric Oxide in Patients Undergoing Maintenance Hemodialysis.
Article in Hemodialysis international. International Symposium on Home Hemodialysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Relationship Between Periodontitis and Nitric Oxide in Patients Undergoing Maintenance Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe inflammatory processes associated with periodontitis have been implicated in the development and progression of systemic diseases, including chronic kidney disease (CKD). Notably, individuals with CKD frequently exhibit shared risk factors with those affected by periodontitis, such as hypertension, smoking, and diabetes mellitus. Nitric oxide (NO), a free radical with diverse physiological and pathological roles, exerts both anti-inflammatory (e.g., vasodilation, modulation of platelet function) and pro-inflammatory effects, the latter of which have been observed in patients with CKD.
aimsThis study aimed to investigate the relationship between nitric oxide levels in saliva and plasma and various periodontal parameters in patients with chronic kidney disease (CKD), in comparison to a control group without CKD.
methodsThis study enrolled 90 participants seeking dental treatment. The participants were divided into two groups: a CKD group (n = 40) consisting of patients undergoing dialysis or hemodialysis treatment at the Pró-Renal Foundation Dental Clinic, and a control group (n = 50) comprising individuals without CKD who were receiving treatment at the UFPR Dental Clinic. Two calibrated examiners conducted comprehensive periodontal examinations for all participants. Additionally, saliva samples were collected from each participant to assess pH, flow rate, and nitric oxide levels. Venous blood samples were also obtained to quantify plasma nitric oxide concentrations.
resultsPatients in the CKD group exhibited significantly poorer periodontal health compared to the control group (p < 0.05), characterized by a larger Periodontal Inflamed Surface Area, greater probing depth, increased clinical attachment level, and a higher visual plaque index (p < 0.05). Furthermore, the CKD group presented with significantly reduced salivary flow (p < 0.05). Notably, this group also showed elevated levels of both nitrate and nitrite in saliva and serum (p < 0.05) compared to the control group. Correlation analyzes revealed significant positive associations between nitrate and nitrite levels (in both plasma and saliva) and several periodontal variables: probing depth (r = 0.38 and 0.41, respectively), clinical attachment level (r = 0.40 and 0.38, respectively), and Periodontal Inflamed Surface Area (r = 0.27 and 0.48, respectively). Conversely, nitrate and nitrite levels in both fluids showed significant negative correlations with glomerular filtration rate (GFR) (r = -0.55 and -0.40, respectively). The visual plaque index demonstrated a significant positive correlation only with salivary nitrate and nitrite levels (r = 0.23), highlighting the potential influence of oral biofilm on nitric oxide metabolism. Interestingly, the comparable levels of nitrate and nitrite observed in saliva and plasma suggest that saliva may be a suitable non-invasive biofluid for biomarker analysis in this context.
conclusionThis study revealed a positive correlation between the visual plaque index and salivary nitric oxide levels in the studied population. However, further research involving specific analysis of the oral biofilm composition and its dynamic role within the nitric oxide entero-salivary cycle in these patients is warranted to elucidate this relationship fully.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.