ArticleFrontiers in medicine2025
Diagnostic and prognostic biomarkers in autoimmune hepatitis-associated cirrhosis: insights into TBil, CD38, IL-22, TSP-1, GAL-3, and Cyc-C.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immunomodulatory role and therapeutic potential of thrombospondin-1 during infectious diseases and autoimmunity.BMC biology · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Autoimmune hepatitis (AIH) is a chronic inflammatory disease that can progress to cirrhosis and liver failure. While various biomarkers have been associated with AIH progression and prognosis, their specific roles in diagnosing, predicting, and managing cirrhosis, particularly in compensated cirrhosis, remain unclear. Accurately predicting 2-year survival and clinical outcomes for patients with compensated cirrhosis is a critical challenge. Methods: This study analyzed clinical data from non-cirrhotic and cirrhotic AIH patients to identify factors influencing cirrhosis development and prognosis. Serum and nutritional indices were compared between groups with differing prognoses. The diagnostic efficacy of TSP-1, Gal-3, Cys-C, AIb, and PA was evaluated in compensated cirrhosis patients, and their prognostic value was validated using linear regression and Cox proportional hazards models. Results: No significant differences in gender, age, BMI, hypertension, diabetes history, or AMA positivity were observed between the non-cirrhotic AIH and cirrhotic AIH groups. However, TBil levels were significantly higher, and CD38 and IL-22 levels were significantly lower in the cirrhosis group. Multivariate logistic regression identified elevated TBil and reduced CD38 and IL-22 levels were associated with increased cirrhosis risk. Prognosis analysis revealed that patients with good outcomes had significantly lower TSP-1, Gal-3, and Cys-C levels and higher AIb and PA levels than those with poor outcomes. Cox proportional hazards modeling identified TSP-1, Gal-3, and Cys-C as independent risk factors and AIb and PA as protective factors influencing 2-year survival. Conclusion: This study underscores the critical roles of TBil, CD38, and IL-22 in cirrhosis development among AIH patients and validates the diagnostic and prognostic significance of TSP-1, Gal-3, Cys-C, AIb, and PA in compensated cirrhosis. These biomarkers facilitate early risk identification and inform clinical decision-making, contributing to improved management and outcomes for AIH patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.