Evidence map›Paper›PMID 40417584›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2024

Enhancing Antibiotic Stewardship: A Machine Learning Approach to Predicting Antibiotic Resistance in Inpatient Care.

Fateme Nateghi Haredasht, Manoj V Maddali, Stephen P Ma, Amy Chang, Grace Y E Kim, Niaz Banaei, Stanley Deresinski, Mary K Goldstein, Steven M Asch, Jonathan H Chen

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Cultryx: Precision Diagnostic Stewardship for Blood Cultures Using Machine Learning.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fateme Nateghi HaredashtStanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.
Manoj V MaddaliStanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.
Stephen P MaDivision of Hospital Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Amy ChangDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Grace Y E KimStanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.
Niaz BanaeiDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Stanley DeresinskiDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Mary K GoldsteinDepartment of Health Policy, Stanford University School of Medicine, Stanford, CA, USA.
Steven M AschDivision of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Jonathan H ChenStanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.

Funding

Measuring and Predicting Appropriate Antibiotic Use to Combat Resistant BacteriaR01AI178121 · NIAID · STANFORD UNIVERSITY · PI JONATHAN H. CHEN · 2023 to 2026
$3.1M
NIAID NIH HHS R01 AI178121
6 · The paper itself

Abstract

Antibiotics have been crucial in advancing medical treatments, but the growing threat of antibiotic resistance challenges these achievements and emphasizes the need for innovative stewardship strategies. In this study, we developed machine learning models, 'personalized antibiograms', to predict antibiotic resistance across five key antibiotics using Stanford's electronic health record data of 49,872 urine, blood, and respiratory infections. We aimed to ascertain the efficacy of these models in predicting antibiotic susceptibility and identify the clinical factors most indicative of resistance. Employing LightGBM, we incorporated demographics, prior resistance, prescriptions, and comorbidities as features. The models demonstrated notable discriminative ability, with AUROCs between 0.74 and 0.78, and highlighted prior resistance and prescriptions as significant predictive factors. The high specificity demonstrates machine learning models' potential to inform antibiotic de-escalation, aiding stewardship without risking safety. By leveraging machine learning with relevant clinical features, we show that it is feasible to improve empirical antibiotic prescribing.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipDrug Resistance, BacterialDrug Resistance, MicrobialMachine LearningElectronic Health RecordsHumansInpatientsMicrobial Sensitivity TestsAnti-Bacterial Agents

Identifiers

PMID40417584
PMCPMC12099390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.