Evidence map›Paper›PMID 40417512›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2024

Artificial Intelligence-assisted Biomedical Literature Knowledge Synthesis to Support Decision-making in Precision Oncology.

Ting He, Kory Kreimeyer, Mimi Najjar, Jonathan Spiker, Maria Fatteh, Valsamo Anagnostou, Taxiarchis Botsis

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ting HeSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Kory KreimeyerSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Mimi NajjarSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Jonathan SpikerSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Maria FattehSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Valsamo AnagnostouSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Taxiarchis BotsisSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicineU01CA274631 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANAGNOSTOU, VALSAMO, BOTSIS, TAXIARCHIS · 2023 to 2025
$1.2M
NCI NIH HHS P30 CA006973NCI NIH HHS U01 CA274631
6 · The paper itself

Abstract

The delivery of effective targeted therapies requires comprehensive analyses of the molecular profiling of tumors and matching with clinical phenotypes in the context of existing knowledge described in biomedical literature, registries, and knowledge bases. We evaluated the performance of natural language processing (NLP) approaches in supporting knowledge retrieval and synthesis from the biomedical literature. We tested PubTator 3.0, Bidirectional Encoder Representations from Transformers (BERT), and Large Language Models (LLMs) and evaluated their ability to support named entity recognition (NER) and relation extraction (RE) from biomedical texts. PubTator 3.0 and the BioBERT model performed best in the NER task (best F1-score 0.93 and 0.89, respectively), while BioBERT outperformed all other solutions in the RE task (best F1-score 0.79) and a specific use case it was applied to by recognizing nearly all entity mentions and most of the relations. Our findings support the use of AI-assisted approaches in facilitating precision oncology decision-making.

Indexed as

Artificial IntelligenceInformation Storage and RetrievalMedical OncologyNatural Language ProcessingNeoplasmsPrecision MedicineHumans

Identifiers

PMID40417512
PMCPMC12099343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.