Evidence map›Paper›PMID 40417462›Full record

ReviewAMIA ... Annual Symposium proceedings. AMIA Symposium2024

Variation in Phenotype Definitions in Observational Clinical Research: A Review of Three Conditions.

Azza Shoaibi, Anna Ostropolets, James Weaver, Gowtham A Rao, Asieh Golozar, Joel Swerdel, Vojtech Huser, Atif Adam, Thamir Alshammari, Nnabuchi Anikpezie and 14 more

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Azza ShoaibiJanssen Research & Development, Titusville, NJ, USA.
Anna OstropoletsJanssen Research & Development, Titusville, NJ, USA.
James WeaverJanssen Research & Development, Titusville, NJ, USA.
Gowtham A RaoJanssen Research & Development, Titusville, NJ, USA.
Asieh GolozarOdysseus Data Services, Cambridge, MA, USA.
Joel SwerdelJanssen Research & Development, Titusville, NJ, USA.
Vojtech HuserOdysseus Data Services, Cambridge, MA, USA.
Atif AdamIQVIA Ltd., Boston, MA, USA.
Thamir AlshammariKing Saud University, Riyad, Saudi Arabia.
Nnabuchi AnikpezieDepartment of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
William A BaumgartnerUniversity of Colorado School of Medicine, Aurora, CO, USA.
Milou BrandReal World Solutions, IQVIA, Cambridge, MA, USA.
Ruochong FanWashington University in St. Louis, St. Louis, MO, USA.
Andrew S KanterDepartment of Biomedical Informatics, Columbia University, New York, USA.
Dave KernJanssen Research & Development, Titusville, NJ, USA.
Septi MelisaInternational PhD Program in Biotech and Healthcare M-anagement, Taipei Medical University, Taipei, Taiwan.
Evan MintyO'Brien Institute for Public Health, University of Calgary, Canada.
Jessica MoJohns Hopkins University School of Medicine, Baltimore, MD.
Bolu OluwaladeThe Children's Hospital of Philadelphia, PA, USA.
Lisa M SchillingUniversity of Colorado School of Medicine, Aurora, CO, USA.
Hayden SpenceAptive Resources LLC, Alexandria, VA, USA.
Jacqueline C StockingDepartment of Internal Medicine, Davis School of Medicine, University of California, California, USA.
Linying ZhangWashington University in St. Louis, St. Louis, MO, USA.
Patrick RyanJanssen Research & Development, Titusville, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study examined the heterogeneity of phenotype algorithms (PA) in literature on Alzheimer's disease (AD), major depressive disorder (MDD), and pulmonary arterial hypertension (PAI), focusing on the impact of PA differences on patient overlap and incidence rate variability across conditions in six observational databases. We reviewed 49 replicated PAs (13 for AD, 23 for MDD, and 13 for PAI) and found significant heterogeneity. These varied PAs identified distinct patient cohorts, resulting in significant incidence rate heterogeneity. Despite some papers reporting primary condition codes and inclusion. comprehensive documentation ensuring reproducibility was often lacking, underscoring the need for more transparent and robust research practices.

Indexed as

AlgorithmsAlzheimer DiseaseHypertension, PulmonaryMajor Depressive DisorderObservational Studies as TopicPhenotypeHumans

Identifiers

PMID40417462
PMCPMC12099327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.