SynthesisGlobal heart2025
Relationship Between Leptin and Heart Failure: A Meta-Analysis.
Synthesis in Global heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact of a Hypocaloric Diet on Prognostic Biomarkers of Endothelial Dysfunction: A Prospective Study.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Heart failure (HF) is a diverse and potentially fatal condition affecting more than 60 million people worldwide. Previous studies have identified a close relationship between leptin levels and HF, and that leptin levels in patients with HF are higher than those in healthy individuals. However, some studies have reported inconsistent results. Therefore, the association between leptin levels and HF remains controversial. Methods: A literature search was conducted on the Web of Science, Wiley Online Library, Embase, and PubMed databases. The title or abstract search term 'leptin' was used in combination with 'heart failure' and 'HF'. Meta-analysis results were reported as standardized mean differences (SMD) with corresponding 95% confidence intervals (CI). Results: Eighteen studies comprising 1149 patients with HF and 622 healthy controls were included in the meta-analysis. Leptin levels in patients with HF were significantly higher than those in healthy individuals (SMD, 0.54; 95% CI [0.15, 0.93]). Conclusions: To our knowledge, this systematic review is the first to evaluate the relationship between leptin and HF. Determining the role of leptin in HF will significantly contribute to its diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.