ArticleInternational journal of clinical pediatric dentistry2025
An Innovative Phyto-mediated Nanocomposite-modified Glass Ionomer Cement: A Detailed Study on Synthesis, Cytotoxicity, Anti-inflammatory Effects, Antimicrobial Activity, Mechanical Performance, and Solubility.
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Green-synthesized nanoparticles for glass ionomer cement reinforcement: a systematic review of their antimicrobial, mechanical, and physicochemical properties.BMC oral health · 2026Pooled it
- Marine macroalgae-mediated ultrasonic-assisted green synthesis of CuO nanoparticles embedded in starch/PVA electrospun nanoscaffolds for in vitro α-amylase and α-glucosidase inhibitory activity.Scientific reports · 2026Article
- Evaluating the antimicrobial effect, compressive strength and fluoride release of glass ionomer cement modified with Triphala.Scientific reports · 2025Article
- Evaluating immunohistochemical and genetic expression of green-mediated nano-enhanced glass ionomer cement: An animal model study.Journal of conservative dentistry and endodontics · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Glass ionomer cement (GIC), or polyalkenoate cement, is popular for esthetic restorations due to its tooth-bonding ability but suffers from low mechanical strength, abrasion resistance, and moisture sensitivity, leading to the search for better alternatives. Aim: To evaluate the cytotoxicity, anti-inflammatory, antimicrobial, mechanical properties, and solubility of phyto-mediated nanocomposite-modified GIC. Materials and methods: Chitosan-titanium-zirconia-hydroxyapatite (Ch-Ti-Zr-HA) nanocomposites were synthesized using a single-step phyto-mediated process and added to GIC at 3, 5, and 10% concentrations (groups I, II, and III), with conventional GIC as the control (group IV). Characterization was done, and the effects on cytotoxicity, anti-inflammatory response, antimicrobial activity, compressive strength, flexural strength, microhardness, and solubility were assessed and analyzed using one-way analysis of variance (ANOVA) and the Tukey Results: Characterization confirmed all particles were within the nanoscale. A 10 wt% concentration of phyto-mediated Ch-Ti-Zr-HA nanocomposite enhanced antimicrobial activity against Conclusion: Our findings indicate that 10% phyto-mediated Ch-Ti-Zr-HA nanocomposite-modified GIC excels in antibacterial activity, compressive and flexural strength, microhardness, and solubility, outperforming conventional GIC and showing potential for enhanced dental applications. How to cite this article: Alex A, Paulraj J, Maiti S,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.