Evidence map›Paper›PMID 40417288›Full record

ArticleChemical science2025

Targeted recognition, fluorescent tracking and augmented killing of multi-bacterial infections

Zhenyue Su, Ling-Hong Xiong, Jing Zhang, Ben Zhong Tang, Xuewen He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. MicroRNA-triggeredNational science review · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhenyue SuState Key Laboratory of Bioinspired Interfacial Materials Science, The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 China xheao@suda.edu.cn.
Ling-Hong XiongSchool of Public Health, Suzhou Medical College of Soochow University, Soochow University Suzhou 215123 China xionglinghong@suda.edu.cn.ORCID https://orcid.org/0000-0003-3241-6310
Jing ZhangState Key Laboratory of Bioinspired Interfacial Materials Science, The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 China xheao@suda.edu.cn.
Ben Zhong TangSchool of Science and Engineering, Guangdong Basic Research Center of Excellence for Aggregate Science, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen) Guangdong 518172 China tangbenz@cuhk.edu.cn.ORCID https://orcid.org/0000-0002-0293-964X
Xuewen HeState Key Laboratory of Bioinspired Interfacial Materials Science, The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 China xheao@suda.edu.cn.ORCID https://orcid.org/0000-0002-8414-5164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate identification and elimination of multi-bacterial infections are critical due to their significant threat to human health, the complexity of synergistic pathogenic mechanisms and their pivotal role in accelerating antibiotic resistance. Here, we developed a multiplex phage-based fluorescence assay using encoded magnetic nanobeads and multifunctional alkaline phosphatase (ALP)-activatable aggregation-induced emission (AIE) probes for synchronously sensitive detection and efficient elimination of multiple pathogenic bacteria. Preselected phages were covalently conjugated to magnetic nanobeads to form a phage cocktail recipe, enabling specific and precise separation of target bacteria from mixed samples. The high expression of ALP within bacteria triggers enzymatic cleavage of AIE probes, forming luminescent aggregates for sensitive detection, while quinone methide species generated

Identifiers

PMID40417288
PMCPMC12096331

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.