Evidence map›Paper›PMID 40417281›Full record

ArticleJournal of cellular immunology2024

Evaluating the Role of the Renin-angiotensin System in COVID-19: Implications for ACE Inhibitor and ARB Use During SARS-CoV-2 Infection.

Sarah R Tritsch, Evelyn Mendoza-Torres, Mónica Gómez-Pulido, Jairo Castellar-López, Rebecca Lynch, Carlos Herrera Gomez, Hana Akselrod, Adrienne Poon, Sam Simmens, Christopher N Mores and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarah R TritschGeorge Washington University, Washington, D.C., 20037, USA.
Evelyn Mendoza-TorresFaculty of Health, Exacts and Natural Sciences, Universidad Libre, Barranquilla, Colombia.
Mónica Gómez-PulidoFaculty of Health, Exacts and Natural Sciences, Universidad Libre, Barranquilla, Colombia.
Jairo Castellar-LópezFaculty of Health, Exacts and Natural Sciences, Universidad Libre, Barranquilla, Colombia.
Rebecca LynchGeorge Washington University, Washington, D.C., 20037, USA.
Carlos Herrera GomezGeorge Washington University, Washington, D.C., 20037, USA.
Hana AkselrodGeorge Washington University, Washington, D.C., 20037, USA.
Adrienne PoonGeorge Washington University, Washington, D.C., 20037, USA.
Sam SimmensGeorge Washington University, Washington, D.C., 20037, USA.
Christopher N MoresGeorge Washington University, Washington, D.C., 20037, USA.
Gary SimonGeorge Washington University, Washington, D.C., 20037, USA.
Lauren C RayUniversity of the Incarnate Word, San Antonio, TX, USA.
Sarah ConwayGeorge Washington University, Washington, D.C., 20037, USA.
Aileen Y ChangGeorge Washington University, Washington, D.C., 20037, USA.

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
The role of IL-2 therapy for Relapsing-Remitting Chikungunya ArthritisK23AR076505 · NIAMS · GEORGE WASHINGTON UNIVERSITY · PI CHANG, AILEEN · 2020 to 2022
$466k
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876NIAMS NIH HHS K23 AR076505
6 · The paper itself

Abstract

This study aimed to investigate the role of the renin-angiotensin system (RAS) in COVID-19, particularly focusing on key components such as ACE, ACE2, and their related peptides, angiotensin-(1-7) and angiotensin-(1-9). Using serum samples from healthy controls and both non-severe and severe COVID-19 patients, ELISA assays revealed no significant differences in these RAS components between the groups. In addition,

Indexed as

Cardiovascular diseaseCoronavirus diseaseCOVID-19DiabetesHypertension

Identifiers

PMID40417281
PMCPMC12101613

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.