ArticleAlzheimer's & dementia (New York, N. Y.)
Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS-HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Unfavorable Social Determinants of Health Are Associated with Lower Cognitive Performance in Non-Hispanic Black Men - The HABS-HD Study.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS-HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness.Alzheimer's & dementia (New York, N. Y.)Article
- Sex differences in blood pressure hemodynamics and white matter hyperintensity volume across racial ethnic groups-HABS-HD.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
10 authors.
Funding
Abstract
introductionThis study examined whether previously identified psychosocial behavioral phenotypes differed on structural neuroimaging markers.
methodsLatent profile analysis (LPA) employed in a sample of 1820 community-dwelling older adults (1118 Hispanic and 702 Black) replicated previous Low Resource/Low Distress, High Resource/Low Distress, and Low Resource/High Distress phenotype classifications. Analyses of covariance (ANCOVAs) adjusting for relevant factors examined phenotype differences on neuroimaging outcomes of predicted brain age gap (BAG) (DeepBrainNet
resultsThe Low Resource/Low Distress and Low Resource/High Distress phenotypes had significantly higher predicted BAGs relative to the High Resource/Low Distress phenotype, and the Low Resource/High Distress group displayed significantly lower hippocampal volumes and meta-temporal cortical thickness relative to High Resource/Low Distress phenotype. DISCUSSION: Results highlight there are neurostructural variations across psychosocial behavioral phenotypes and indicate the Low Resource/High Distress group may be at risk for ADRD. Highlights: Brain age gap (BAG), hippocampal volumes, and cortical thickness differences were tested.The High Resource/Low Distress phenotype had the most favorable imaging outcomes.The Low Resource/High Distress phenotype demonstrated the poorest imaging outcomes.Risk for Alzheimer's disease and related dementias (ADRD) may differ across psychosocial behavioral phenotypes.
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