Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish.

Yajun Wang, Gaoqian Xu, Haoyi Li, Jing Gao, Xueqing Du, Wanyue Jiang, Guangdong Ji, Zhenhui Liu

Abstract read

In one paragraph

Article in Marine life science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yajun Wang *College of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Gaoqian Xu *College of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Haoyi LiCollege of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Jing GaoCollege of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Xueqing DuCollege of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Wanyue JiangCollege of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Guangdong JiCollege of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Zhenhui LiuCollege of Marine Life Sciences, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex determination and differentiation play crucial biological roles in sexual reproduction in vertebrates, including zebrafish. Nevertheless, the intricate molecular mechanisms governing these processes have remained enigmatic. In this study, we showed a pivotal role played by zinc finger GATA-like protein-1 (Zglp-1) in sex differentiation in zebrafish. Our findings revealed that homozygous mutants having no Zglp-1 exhibited a female-to-male sex reversal, ultimately resulting in the development of fertile males. Within the pivotal phase of sexual differentiation, Supplementary Information: The online version contains supplementary material available at 10.1007/s42995-025-00299-5.

Indexed as

Sex differentiationSex reversalSF-1ZebrafishZGLP-1Zinc finger

Identifiers

PMID40417248

DOI10.1007/s42995-025-00299-5

PMCPMC12102022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.