Evidence map›Paper›PMID 40417237›Full record

ArticleFrontiers in genetics2025

Long-read sequencing reveals absence of 5mC in Ogataea parapolymorpha DL-1 genome and introduces telomere-to-telomere assembly.

Andrey Eremin, Alexander Sergeev, Arthur Kopylov, Vladimir Rodin, Daniil Malyshev, Tatiana Panova, Igor Polyakov, Maria Zvereva

Abstract read
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Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrey EreminLomonosov Moscow State University, Moscow, Russia.
Alexander SergeevLomonosov Moscow State University, Moscow, Russia.
Arthur KopylovLomonosov Moscow State University, Moscow, Russia.
Vladimir RodinLomonosov Moscow State University, Moscow, Russia.
Daniil MalyshevLomonosov Moscow State University, Moscow, Russia.
Tatiana PanovaLomonosov Moscow State University, Moscow, Russia.
Igor PolyakovLomonosov Moscow State University, Moscow, Russia.
Maria ZverevaLomonosov Moscow State University, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: We used long-read sequencing technology to achieve a telomere-to-telomere (T2T) genome assembly of Results: Key findings include the absence of 5 mC DNA modification and the presence of 6 mA in the genome, unusual telomere regulation mechanism based on the addition of non-telomeric dT and the introduction of long-read enhanced telomere-to-telomere assembly. Conclusion: This work provides deeper insights into the yeast's genome organization and methylation patterns, contributing to the understanding of its genetics and therefore potential biotechnological applications.

Indexed as

genomicslong-read sequencingmethylomicsOgataea parapolymorpha DL-1T2T-assembly

Identifiers

PMID40417237
PMCPMC12098377

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.