ArticleThe Malaysian journal of medical sciences : MJMS2025
Exploration of Oral Sodium Bicarbonate Acceptance and Adherence among Chronic Kidney Disease Patients with Metabolic Acidosis: A Multicentre Cross-Sectional Survey.
Article in The Malaysian journal of medical sciences : MJMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral sodium bicarbonate is recommended for treating metabolic acidosis in chronic kidney disease (CKD). However, limited information exists on patient preferences between sodium bicarbonate tablets and powdered solutions. This study aimed to provide baseline data regarding the acceptance and adherence of patients with CKD to oral sodium bicarbonate therapy. Methods: This prospective multicentre cross-sectional study was conducted across five Malaysian government hospitals involving adult patients with pre-dialysis CKD. A questionnaire assessed demographics, clinical characteristics, bicarbonate treatment, and included the Medication Acceptance Questionnaire (MAQ) (convenience, taste, appearance, efficacy, and tolerability), along with an individual adherence assessment. Results: Among 203 patients analysed, the median age was 60 years (interquartile range [IQR], 16 years), and the majority were at stage 5 ( Conclusion: Tablet formulation of sodium bicarbonate was associated with higher patient acceptance and adherence, potentially leading to improved long-term clinical outcomes.
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