Evidence map›Paper›PMID 40417169›Full record

ArticleChem2025

De novo luciferases enable multiplexed bioluminescence imaging.

Julie Yi-Hsuan Chen, Qing Shi, Xue Peng, Jean de Dieu Habimana, James Wang, William Sobolewski, Andy Hsien-Wei Yeh

Abstract read
In one paragraph

Article in Chem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  7. De Novo Design of High-Performance Cortisol Luminescent Biosensors.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julie Yi-Hsuan ChenDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.
Qing ShiDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.
Xue PengDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.
Jean de Dieu HabimanaDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.
James WangDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.
William SobolewskiDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.
Andy Hsien-Wei YehDepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA.

Funding

De novo design of a generalizable protein biosensor platform for point-of-care testingR00EB031913 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YEH, HSIEN WEI · 2023 to 2025
$747k
NIBIB NIH HHS R00 EB031913
6 · The paper itself

Abstract

We leverage AI-powered

Indexed as

bioassaydeep learningenzyme designFRETluciferasemultiplexed bioluminescence imaging

Identifiers

PMID40417169
PMCPMC12097527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.