ArticleFrontiers in neurology2025
Cognitive implications of white matter microstructural changes in individuals with low heart rate variability: a NODDI study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigated the microstructural integrity of WM and the relationship with the cognitive domains and cognition-related plasma biomarkers in low heart rate variability (HRV). Methods: Our study recruited 44 high HRV and 44 low HRV (Grouping by median of HF). Diffusion Magnetic resonance imaging (MRI) was utilized for the calculation of neurite orientation dispersion and density imaging (NODDI) parameters, and tract-based spatial statistics (TBSS) were employed to explore differential clusters. The fibers covered by these clusters were defined as regions of interest (ROI) for the extraction of NODDI parameter values and the analysis of their correlation with cognitive domains and cognition-related plasma biomarkers. Results: The TBSS analysis unveiled specific cerebral regions exhibiting disparities within the low HRV group high HRV group. These differences were evident in fractional isotropy (FISO; Conclusion: Patients with low HRV exhibit distinctive patterns of microstructural changes in the WM as revealed by the FISO which indicate a decline in white matter integrity, and the relationship between low HRV-related and worse cognitive performance may be attributed to damage of the frontal-corpus callosum pathways.
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