Evidence map›Paper›PMID 40416985›Full record

ReviewFrontiers in immunology2025

The distinct role of IL-34 and IL-35 in gastric cancer.

Zhiyun He, Jie Dang, Xiang Cui, Bo Li, Shisan Bao, Jingchun Fan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Therapeutic potential of targeting macrophage polarization in metastatic gastric cancer: a review on core mechanisms and clinical progress.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhiyun HeGeneral Surgery Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Jie DangCentral Sterile Supply Department, Second Hospital of Lanzhou University, Lanzhou, Gansu, China.
Xiang CuiGeneral Surgery Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Bo LiGeneral Surgery Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Shisan BaoScientific Research Division, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, China.
Jingchun FanSchool of Public Health, Centre for Evidence-based Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) remains a major challenge due to its high mortality and morbidity, despite extensive research. Dysregulated host immunity plays a critical role in carcinogenesis, particularly among susceptible cohorts. In the gastric mucosa of GC patients, a reduction in IL-34 and TAM1, accompanied by an increase in TAM2

Indexed as

InterleukinsStomach NeoplasmsAnimalsGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansTumor MicroenvironmentIL34 protein, humaninterleukin-35, humanInterleukinsgastric cancerIL-34IL-35prognosisTAMs

Identifiers

PMID40416985
PMCPMC12098620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.