Evidence map›Paper›PMID 40416954›Full record

ReviewFrontiers in immunology2025

Systemic lupus erythematosus complicated by severe Guillain-Barré syndrome: case report and literature review.

Lifeng He, Zengrui Zhang, Ying Tan

Abstract readCase ReportsReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lifeng HeDepartment of Neurology, Huzhou Central Hospital, the Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, China.
Zengrui ZhangDepartment of Neurology, Huzhou Central Hospital, the Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, China.
Ying TanDepartment of Neurology, Huzhou Central Hospital, the Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a heterogeneous chronic autoimmune disease characterized by immune-mediated multiple organ injuries in the setting of autoimmunity to nuclear antigens. In rare cases, it can complicated by the damage of peripheral nervous system, manifesting as Guillain-Barré syndrome (GBS). Severe GBS as the initial presentation is highly infrequent and associated with high disability and mortality rates, highlighting the importance of early detection, diagnosis, and treatment. Herein, we reported a successfully treated case of severe SLE-GBS in a 38-year-old male. Furthermore, we summarize the clinical characteristics of severe SLE-GBS reported thus far and propose the possibility of using medium-to-high dose corticosteroids in the acute progression stage of SLE-GBS. This report provides valuable insights for the analysis of disease characteristics and guidance for diagnosis and treatment of such cases.

Indexed as

Guillain-Barre SyndromeLupus Erythematosus, SystemicAdrenal Cortex HormonesAdultHumansMaleTreatment OutcomeAdrenal Cortex Hormonesacute progression stagecase reportGuillain-Barré syndromeperipheral neuropathysystemic lupus erythematosus

Identifiers

PMID40416954
PMCPMC12098485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.