Evidence map›Paper›PMID 40416942›Full record

ReviewTherapeutic advances in infectious disease

Antimicrobial resistance with a focus on antibacterial, antifungal, antimalarial, and antiviral drugs resistance, its threat, global priority pathogens, prevention, and control strategies: a review.

Wubetu Yihunie Belay, Melese Getachew, Bantayehu Addis Tegegne, Zigale Hibstu Teffera, Abebe Dagne, Tirsit Ketsela Zeleke, Samuel Agegnew Wondm, Rahel Belete Abebe, Abebaw Abie Gedif, Abebe Fenta and 3 more

Abstract readReview
In one paragraph

Review in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. A One Health Perspective onMicroorganisms · 2026
    Review
  5. Article
  6. Review
  7. Network-based prediction and real-world patient data observation identify doxycycline as a repurposable drug in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wubetu Yihunie BelayDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.ORCID https://orcid.org/0000-0003-2703-8941
Melese GetachewDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Bantayehu Addis TegegneDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Zigale Hibstu TefferaDepartment of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Abebe DagneDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Tirsit Ketsela ZelekeDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Samuel Agegnew WondmDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.ORCID https://orcid.org/0000-0002-0723-6804
Rahel Belete AbebeDepartment of Clinical Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Abebaw Abie GedifDepartment of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Abebe FentaDepartment of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.ORCID https://orcid.org/0000-0002-0775-5639
Getasew YirdawDepartment of Environmental Health Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Adane TilahunDepartment of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Yibeltal AschaleDepartment of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a significant global health threat by diminishing the effectiveness of once-powerful antimicrobial agents, leading to higher rates of illness and death, along with escalating healthcare costs. While bacterial resistance is a primary concern, resistance is also increasing against antifungal, antiparasitic, and antiviral drugs. Many of the last-resort drugs are becoming less effective due to AMR. Projections indicate that by 2050, AMR could cause up to 10 million deaths annually, making it the leading cause of death worldwide, a situation that could result in a post-antibiotic era with substantially increased morbidity and mortality. This review aims to raise awareness about the dangers of AMR and its potential to become a silent global pandemic. It begins by examining antimicrobial drugs, followed by a discussion on AMR, focusing on resistance to antibacterial, antifungal, antimalarial, and antiviral drugs, along with its effects on health, and the economy, and prioritized global pathogens. Finally, it explores preventive measures and innovative strategies to combat AMR.

Indexed as

antibacterial resistanceantifungal resistanceantimalarial resistanceantimicrobial stewardshipglobal priority pathogensOne Health

Identifiers

PMID40416942
PMCPMC12103682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.