ArticleBiomaterials research2025
From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds.
Article in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Preparation of Multifunctional Hydrogel Loaded with Isochlorogenic Acid A/FeGels (Basel, Switzerland) · 2026Article
- Selenium nanoparticle-loaded microneedle patches promote diabetic oral ulcer healing by regulating the inflammatory microenvironment through upregulation of SELENBP1-mediated mitophagy.Journal of nanobiotechnology · 2026Article
- Engineered pagoda-like dissolvable microneedle patches for synergistic photothermal antibacterial and wound regenerative therapy.Journal of nanobiotechnology · 2026Article
- A Dual-Network Injectable Hydrogel Scaffold Integrating Glycyrrhizic Acid and Acellular Fat Extracts for Synergistic Enhancement of Diabetic Wound Healing.ACS polymers Au · 2026Article
- Multifunctional Metal Composite Hydrogels for Diabetic Wound Therapy.Gels (Basel, Switzerland) · 2025Review
- Sparking angiogenesis by carbon monoxide-rich gold nanoparticles obtained by pulsed laser driven COJournal of nanobiotechnology · 2025Article
- Stimuli-responsive nanozymes for wound healing: From design strategies to therapeutic advances.Materials today. Bio · 2025Review
- Erratum to "From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds".Biomaterials research · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic wounds pose considerable healing challenges due to factors such as impaired angiogenesis, persistent inflammation, elevated levels of reactive oxygen species, and bacterial infections. In this study, we synthesized copper sulfide nanoparticles (NPs) using sericin as a biotemplate and functionalized them with tannic acid-Fe (TA-Fe) metal-phenolic network coatings to create CuS-based nanoenzymes (CuS-Se@TA-Fe NPs). These NPs were integrated into a composite hydrogel formed from polyvinyl alcohol, carboxymethyl chitosan, and borax. The hydrogen bonding between polyvinyl alcohol and carboxymethyl chitosan, combined with the borate ester bonds from borax and the electrostatic interactions with CuS-Se@TA-Fe NPs, resulted in a hydrogel with remarkable adhesion, self-healing capabilities, and shape retention (PCCuT hydrogel). Additionally, the PCCuT hydrogel demonstrated superoxide dismutase and catalase mimetic activities to eliminate excess free radicals, along with excellent photothermal conversion and antimicrobial properties due to the photothermal effect. Both in vitro and in vivo investigations indicated that the PCCuT hydrogel could enhance angiogenesis and promote the transformation of macrophages into the M2 anti-inflammatory phenotype. Notably, in a rat model of diabetic wound infection, the hydrogel exhibited substantial wound-healing benefits. In summary, the PCCuT hydrogel holds promise for advancing the treatment of diabetic wounds complicated by infection.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.