ArticleJAC-antimicrobial resistance2025
Associations between antibiotic consumption intensity and extended-spectrum cephalosporin resistance in nursing homes: a retrospective ecological study.
Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Studies relating the usage of antibiotics with extended-spectrum cephalosporin resistance (ESC-R) rates from clinical isolates in nursing homes (NHs) are rare. We investigated associations between the intensity of NH-level antibiotic consumption (ABC) and the frequency of ESC-R expressing urinary Materials and methods: We used retrospective data on ABC and ESC-R counts aggregated by NH and year between 2017 and 2022 from NHs of canton Vaud in Switzerland. Negative binomial regression was used to relate ABC intensity, expressed as DDDs per 1000 resident days, with counts of ESC-R expressing bacteria. Results: Fifty-four NHs were included cumulatively accounting for 6601 urinary isolates, of which 5028 Conclusion: No association was found between overall ABC and ESC-R rates. Cephalosporin consumption showed a modest association, while for carbapenems this could reflect therapeutic use. These findings highlight the need for enhanced surveillance and resident-level data to better understand antibiotic resistance drivers in this setting.
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