ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Abdominal Massage Decreases Food Intake and Body Weight in High-Fat Diet-Induced Obese Rats Through Upregulating GPR41/GPR43-PYY/GLP-1 Axis.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-pharmacological therapies of traditional Chinese medicine in prediabetes: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
- Probiotic Modulation of Gut Microbiota: Antioxidant Mechanisms and Clinical Benefits in Obesity and Type 2 Diabetes Management.Antioxidants (Basel, Switzerland) · 2026Review
- Therapeutic potential of modulating endogenous PYY expression for controlling overweight and obesity: a narrative review.Frontiers in nutrition · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Abdominal massage has been found to exert an important role in helping people in overcoming obesity. However, the mechanism by which abdominal massage induces weight loss remains largely unclear. Methods: Healthy male Sprague-Dawley (SD) rats were randomly grouped into standard diet control (15% fat content) group and high-fat diet (HFD, 40% fat content) group. After 6 weeks of high-fat feeding, rats in the HFD group were successfully modeled, and then separated into the HFD group and HFD plus abdominal massage group. Rats in the HFD plus abdominal massage group were then subjected to abdominal massage for 12 continuous days. Results: Compared to the HFD group, abdominal massage could decrease body weight, food intake and abdominal fat index (AFI) of HFD-fed rats. Meanwhile, compared to the HFD group, abdominal massage obviously attenuated mucosal epithelial damage and reduced inflammatory cell infiltration in colon mucosal tissues of HFD-fed rats. Furthermore, compared to the HFD group, abdominal massage significantly increased GPR42 and GPR43 levels in the colon tissues of HFD-fed rats, and upregulated the production of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in colon mucosal tissues of HFD-fed rats. Conclusion: Collectively, abdominal massage could decrease food intake and body weight in HFD-induced obese rats through upregulating GPR41/GPR43-PYY/GLP-1 axis.
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