ArticleAnnals of burns and fire disasters2025
Effects of the combination of platelet-rich plasma and stromal vascular fraction on the level of platelet-derived growth factor-bb in the wound remodeling of full-thickness burn injuries in wistar rats.
Article in Annals of burns and fire disasters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Experimental studies have shown that the effects of stromal vascular fractions and platelet-rich plasma on deep dermal burn healing were encouraging. By measuring the blood level of platelet-derived growth factor (PDGF)-BB, we evaluated their effect on full-thickness burns in this study. Forty-eight Wistar rats were separated into four main groups: group A rats were administered combined SVF and PRP injections, group B rats were topically administered Vaseline, group C rats were administered placebo injections, and group D rats were without burns. Depending on the day of euthanasia, these groups were further divided into subgroups (8th hour, 4th day, 7th day, 14th day, and 21st day). Using enzyme-linked immunosorbent assay, the serum level of platelet-derived growth factor-BB was determined. Friedman's test or the analysis of variance test was applied, and p-values under 0.05 were regarded as significant. The PRP+SVFs group had the highest mean PDGF-BB levels overall on days 4, 7, 14 and 21 (1.81±1.04 pg/ml, 1.24±0.41 pg/ml, 2.21±0.60 pg/ml, and 3.10±1.02 pg/ml, respectively). The repeated ANOVA test (Mauchly's test of sphericity) resulted in a p-value of 0.556 (>0.05), indicating that the variance of the PDGF-BB data was the same. Additionally, a p-value of 0.001 demonstrated a significant difference in the levels of PDGF-BB between the groups. Overall, the mean PDGF-BB level by day differed significantly between the PRP+SVFs group and the Vaseline group, the negative control group, and the group of healthy rats.
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40416896PMC12097509What OpenQuestion holds
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