ArticleFrontiers in cardiovascular medicine2025
Ticagrelor combined with aspirin may improve patency of vein graft one year after off-pump coronary artery bypass grafting: a single-center, randomized double-blinded clinical controlled trial.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Time- and risk-dependent effects of dual antiplatelet therapy targeting the P2Y12 receptor after CABG: A network meta-analysis of graft permeability and clinical outcomes.Journal of thrombosis and thrombolysis · 2026Review
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11 authors.
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Abstract
Background: Dual anti-platelet therapy (DAPT) after coronary artery bypass graft surgery (CABG) has drawn a lot of controversy. This study aimed to explore the effects of ticagrelor combined with aspirin (compared with aspirin combined with clopidogrel) on the patency of saphenous vein graft (SVG) after off-pump CABG. Methods: This was a prospective, randomized, double-blinded clinical controlled trial. Participants were first given aspirin (100 mg/d) within 12 h after off-pump CABG, followed by P2Y12 receptor antagonist (Orally, 75 mg/time of clopidogrel, once daily, for Group C and 90 mg/time of ticagrelor, twice daily, for Group T) within 24 h after off-pump CABG for one year. Computed tomography angiography (CTA) was conducted for all patients. The incidence of major adverse cardiac events(MACE), death, stroke, hemorrhage, left ventricular diameter (LVD), and left ventricular ejection fraction (LVEF) of the participants was assessed one year after off-pump CABG based on a 12-month follow-up. Results: A total of 73 participants completed the follow-up, and 219 bypass grafts, including 146 SVGs, were conducted. Notably, 11 bypass grafts (SVGs) were exposed to occlusion (9 in Group C and 2 in Group T). The overall occlusion rates of bypass grafts and SVGs of Groups C and T were significantly different (9/114 vs. 2/105, Conclusions: Compared with clopidogrel, ticagrelor may reduce the occlusion rate of vein grafts after CABG. Clinical Trial Registration: [https://www.chictr.org/], identifier [ChiCTR1900022390].
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