ArticleDrug design, development and therapy2025
Quality by Design Formulation Approach for the Development of Orodispersible Tablets of Dexlansoprazole.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- DoE-guided Development of Hydroxypropyl-β-cyclodextrin Complex-loaded Curcuminoid Orodispersible Tablets for Geriatric Use.AAPS PharmSciTech · 2026Article
- Development of Orally Disintegrating Tablets of StandardizedPharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Dexlansoprazole (DX) is a commercially available proton pump inhibitor (PPI). It is an oral delayed-release (DR) formulation that takes 1-2 h to reach the systemic circulation. To overcome the delayed onset of action of conventional formulation and patient inconvenience, orodispersible tablets (ODTs) have been formulated. Drug delivery systems, especially in elderly and frequent travelers, are limited by conventional dosage forms, and ODTs are an ideal dosage form for the fast onset of action and ease of administration for these patients and are more convenient than conventional tablets for patient compliance. Methods: The formulation was optimized via Design Expert Results: Drug plasma concentrations were analyzed at different time intervals through high-performance liquid chromatography (HPLC). PK Summit Conclusion: The ODTs exhibited good physical characteristics, with a pleasant taste and disintegrated rapidly in the saliva due to the addition of a superdisintegrant and an effervescent pair. Pharmacokinetics revealed a rapid therapeutic effect with good C
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