Evidence map›Paper›PMID 40416796›Full record

Trial reportDrug design, development and therapy2025

Minimum Effective Concentration of Ropivacaine for Ultrasound-Guided RISS Block in VATS: A Biased Coin Design Approach.

Ping Li, Zhongsai Yang, Long Zhang, Ruilan Wu, Manhua Zhu, Junran Xie

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The MECDrug design, development and therapy · 2026
    Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ping LiDepartment of Anesthesiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, 310016, People's Republic of China.
Zhongsai YangDepartment of Anesthesiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, 310016, People's Republic of China.
Long ZhangDepartment of Anesthesiology, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, 315040, People's Republic of China.
Ruilan WuDepartment of Anesthesiology, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang Province, 315040, People's Republic of China.
Manhua ZhuDepartment of Anesthesiology, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang Province, 315040, People's Republic of China.
Junran XieDepartment of Anesthesiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, 310016, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative pain management is essential after video-assisted thoracoscopic surgery (VATS). The rhomboid intercostal and sub-serratus (RISS) block is effective in providing analgesia. This study aims to determine the minimum effective concentration (MEC) of ropivacaine for ultrasound-guided RISS block in patients undergoing VATS, thereby optimizing the analgesia protocol and enhancing its clinical significance. Methods: The biased coin design sequential method and isotonic regression were used. The ropivacaine initial concentration was 0.25% with a gradient of 0.025%. If the previous patient had a negative block, the concentration for the next patient would increase by 0.025%. If positive, the concentration would be adjusted based on biased coin randomization: an 11% chance of reducing it by 0.025% and an 89% chance of keeping it unchanged. MEC Results: A total of 49 patients were included in the analysis. The MEC Conclusion: The MEC

Indexed as

Anesthetics, LocalNerve BlockPostoperative PainRopivacaineThoracic Surgery, Video-AssistedUltrasonography, InterventionalAdultAgedDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedAnesthetics, LocalRopivacaineDose findingMinimum effective concentrationRhomboid intercostal and subserratusRISSRopivacaineUltrasound-guided

Identifiers

PMID40416796
PMCPMC12103202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.