Evidence map›Paper›PMID 40416785›Full record

ReviewMaterials today. Bio2025

Stimulus-responsive cellulose hydrogels in biomedical applications and challenges.

Huaqian Xue, Cong Zhu, Yifan Wang, Qiancheng Gu, Yunyuan Shao, Anqi Jin, Xiaofen Zhang, Lanjie Lei, Yongliang Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huaqian XueKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Cong ZhuSchool of Stomatology, Hunan University of Traditional Chinese Medicine, Changsha, 410208, Hunan, China.
Yifan WangKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Qiancheng GuKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Yunyuan ShaoKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Anqi JinKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Xiaofen ZhangKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Lanjie LeiKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Yongliang LiThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimuli-responsive cellulose hydrogels have garnered significant attention in the biomedical field owing to their extensive applications in tissue engineering and controlled drug delivery systems. Derived from cellulose and its derivatives, they are synthesized through physical or chemical cross-linking techniques, offering notable advantages such as cost-effectiveness and excellent biocompatibility. These hydrogels can respond to environmental stimuli, including pH variations, temperature fluctuations, and light exposure, enabling targeted drug release and promoting tissue regeneration. In tissue engineering, Stimuli-responsive cellulose hydrogels are used for the repair and regeneration of skin, bone, and other critical tissues. In drug delivery, they are optimized for oral, nasal, and ocular administration, as well as advanced cancer therapies. In addition, Stimuli-responsive cellulose hydrogels exhibit significant potential in disease diagnostics, particularly their conductive variants, which show promise in biosensing and diagnostic applications. However, despite their potential, challenges such as immune compatibility, long-term stability, and scalability in production remain barriers to clinical translation. Future research efforts should focus on multifunctional integration, advanced intelligent design, and enhanced stimulus responsiveness to fully unlock their potential in biomedical applications and facilitate their transition from laboratory research to practical use.

Indexed as

Cellulose HydrogelDrug deliveryStimulus-responsiveTissue repair

Identifiers

PMID40416785
PMCPMC12098173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.