ArticleMaterials today. Bio2025
Fast shape memory function and personalized PLTMC/SIM/MBG composite scaffold for bone regeneration.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Shape Memory Polymers as Functional Platforms for Dynamic Tissue Engineering and Regenerative Medical Devices.Polymers · 2026Review
- Review
- Advanced Design Concepts for Shape-Memory Polymers in Biomedical Applications and Soft Robotics.Polymers · 2026Review
- Sequential treatment of infectious bone defects with three dimensional-printed body temperature-responsive shape memory scaffold coated with metal-polyphenol layers.Burns & trauma · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthopedic clinical practice faces significant challenges in treating critical-sized bone defects due to extensive tissue damage and prolonged healing. To address these limitations, this study integrated shape-memory polymers with 3D printing to engineer bioactive scaffolds composed of poly(l-lactide-co-trimethylene carbonate) (PLTMC), simvastatin (SIM), and mesoporous bioactive glass (MBG) via low-temperature rapid prototyping. The PLTMC/SIM/MBG composite scaffold exhibited exceptional porosity (78.5 % ± 1.5 %) and load-bearing compressive strength (66.33 ± 1.44 MPa at 30 % MBG). In addition, its thermoresponsive shape-memory behavior enabled intraoperative molding to precisely conform to defect geometries, while the sustained release of SIM and MBG ionic exchange together created a bioactive microenvironment. Mechanistically, the scaffold activated the Wnt pathway to enhance the osteogenic differentiation of mesenchymal stem cells, maintaining cytocompatibility. In vivo, directional bone regeneration occurred along the degradable scaffold, driven by synergistic topographical guidance from 3D-printed pores and biochemical cues from SIM and MBG. The shape-adaptive design preserved mechanical continuity with the host bone during remodeling. These results demonstrate a personalized solution for large defects, merging surgical adaptability through shape-memory functionality with bioactive efficacy via structural and biochemical synergy, overcoming the limitations of conventional implants in anatomical matching and regenerative performance.
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Registered trials
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