ArticleNPP - digital psychiatry and neuroscience2025
Traumatic stress alters neural reactivity to visual stimulation.
Article in NPP - digital psychiatry and neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Re-experiencing trauma: Occipital lobe resting-state functional connectivity in posttraumatic stress disorder.Psychiatry research. Neuroimaging · 2026Article
- Stress-related neuroplasticity and developmental vulnerability in functional neurological disorder: from adverse experience to maladaptive overlearning.Frontiers in molecular neuroscience · 2026Review
- Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury.Brain communications · 2026Article
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Abstract
Traumatic stress is a precursor to the development of posttraumatic stress disorder (PTSD). Emergent research suggests visual processing regions may be relevant to PTSD development; however, no previous research to date has investigated the potential effects of trauma exposure on neural reactivity to non-affective visual stimulation. In the present study, 24 recently trauma-exposed (RTE) and 16 without recent exposure to trauma (NRTE) individuals completed functional magnetic resonance imaging during alternating blocks of flickering checkerboard presentations and attention/rest with an attentional check. RTE participants were recruited within ~2-4 weeks of trauma, and PTSD symptoms were assessed both at the time of the magnetic resonance imaging scan and 6 months following trauma exposure. RTE participants showed greater deactivation within the visual cortex compared to NRTE participants. Further, NRTE participants showed greater neural reactivity within the dorsomedial prefrontal cortex during stimulation compared to attention/rest, while no difference was observed in RTE participants. Connectivity analyses also revealed that visual cortex to paracentral gyrus connectivity was greater during stimulation compared to attention/rest, but only for the NRTE participants. Finally, neural reactivity to visual stimulation was negatively associated with PTSD symptoms within the RTE group. Our findings suggest that trauma exposure is associated with acute alterations in the neural function that underlies basic visual processing. Furthermore, trauma-induced variability in visual circuit function may be related to the development and expression of PTSD symptoms.
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