Evidence map›Paper›PMID 40416739›Full record

ReviewFrontiers in aging neuroscience2025

Early diagnosis of Parkinson's disease: biomarker study.

Jing Li, Mei Zhang, Chuan-Qing Yu, Min Xue, Pan-Pan Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing LiDepartment of Neurology, The First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China.
Mei ZhangDepartment of Neurology, The First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China.
Chuan-Qing YuDepartment of Neurology, The First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China.
Min XueDepartment of Neurology, The First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China.
Pan-Pan HuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a common chronic degenerative disease with age-dependent increasing prevalence in the elderly. Non-motor symptoms include sensory deficiencies, autonomic dysfunction, psychological and cognitive abnormalities; while motor symptoms are bradykinesia, myotonia, resting tremor, and postural balance difficulties. The clinical diagnosis of PD depends mainly on patients' medical history and physical examination. It is highly important to realize early detection of PD, and biomarkers are a valuable tool in this regard. The present study reviewed the findings of researches from the last few years, involving the advancements in the study of PD biomarkers in blood, cerebrospinal fluid, saliva, urine, tears, imaging, and pathology.

Indexed as

biomarkersbloodcerebrospinal fluidimagingParkinson’s diseasesalivatearsurine

Identifiers

PMID40416739
PMCPMC12098601

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.