ArticleFrontiers in public health2025
Association between micronutrient supplementation during pregnancy and preterm birth: evidence from a large-scale children survey and Mendelian randomization study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preterm birth (PTB) is a leading cause of neonatal mortality and under-five mortality worldwide, with long-term health impacts. While micronutrient supplementation shows promise in preventing PTB, its effectiveness remains controversial due to confounding factors. This study aims to elucidate the association between micronutrient supplementation and PTB risk by analyzing a large-scale children survey and employing Mendelian Randomization (MR) to address confounding factors. Methods: This study recruited 66,728 mother-child dyads in Longhua District, Shenzhen, China in 2021. Participants provided information on micronutrient supplementation (multinutrient, folic acid, calcium, and iron) through a structured questionnaire. Logistic regression assessed the association between micronutrient supplementation and PTB in crude, adjusted, and full-inclusion models. MR analysis used summary-level GWAS data from the UK Biobank and FinnGen consortiums. The main MR analyses employed inverse variance weighting (IVW), with sensitivity analyses including MR Egger regression, weighted median, weighted mode, simple mode, and MR-PRESSO. Results: Observational analysis indicated folic acid (OR = 0.80, 95%CI: 0.72-0.89), calcium (OR = 0.88, 95%CI: 0.80-0.96), and iron (OR = 0.92, 95%CI: 0.86-0.98) as protective factors against PTB, especially in co-supplementation, while multinutrient supplementation showed no significant effect. MR analysis indicating a consistent protective effect of calcium (OR Conclusion: Combining observational data with genetic causal inference, our study confirms the protective roles of folic acid, calcium, and iron against PTB, with MR particularly highlighting calcium's causal association with reduced PTB risk. These findings provide a comprehensive understanding and underscore the importance of targeted nutritional interventions, especially calcium, in prenatal care for PTB prevention. However, given the limitations of the self-reported data and the lack of information on doses used in our study, future prospective studies with more detailed micronutrient information are needed to provide more comprehensive evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.