Evidence map›Paper›PMID 40416649›Full record

ArticleRegenerative biomaterials2025

Tartaric acid-branched polyethyleneimine carbon dots promote repair of bone defect via osteogenic differentiation.

Soon Chul Heo, Hae Won Shin, Dong Joon Lee, Franklin Garcia-Godoy, Bo Ram Keum, Yong Hoon Kwon, Hyung Joon Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soon Chul HeoDepartment of Oral Physiology, Periodontal Diseases Signaling Network Research Center, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
Hae Won ShinDepartment of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Dong Joon LeeOral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Franklin Garcia-GodoyDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Bo Ram KeumDepartment of Oral Physiology, Periodontal Diseases Signaling Network Research Center, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
Yong Hoon KwonDepartment of Dental Materials, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
Hyung Joon KimDepartment of Oral Physiology, Periodontal Diseases Signaling Network Research Center, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.ORCID https://orcid.org/0000-0002-2962-9553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treating bone defects is a critical challenge in regenerative medicine. Carbon nanomaterials, with their unique physicochemical properties, offer significant potential for enhancing bone regeneration. In this study, we developed tartaric acid (TA)-based carbon dots (CDs) by synthesizing TA with branched polyethyleneimine (bPEI). These TA-bPEI CDs were systematically evaluated to determine their effects on osteogenic differentiation in human bone marrow-derived mesenchymal stem cells (BMSCs) and their capacity to repair calvarial defects in an

Indexed as

bone repairbranched polyethyleneiminecarbon dotsosteogenesistartaric acid

Identifiers

PMID40416649
PMCPMC12098262

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.