Evidence map›Paper›PMID 40416612›Full record

SynthesisPeerJ2025

Hydrogen sulfide protects against cisplatin-induced experimental nephrotoxicity in animal models: a systematic review and meta-analysis.

Zhenyuan Han, Tianyu Deng, Dechao Yan, Yutao Jia, Jing Tang, Xiaoyan Wang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhenyuan Han *Department of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Tianyu Deng *Department of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Dechao YanDepartment of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Yutao JiaDepartment of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Jing TangCollaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Xiaoyan WangDepartment of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.ORCID 0000-0001-7406-5008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cisplatin-induced acute kidney injury (cis-AKI) is not rare in oncological patients clinically, but there are limited prevention and treatment methods available. The efficacy of hydrogen sulfide (H Methods: According to the pre-registered program (PROSPERO: CRD 42023463779), we searched PubMed/Medline, Embase, and Web of Science databases using the keywords: hydrogen sulfide, cisplatin, acute kidney injury, and alternatives. A total of 13 articles met the inclusion criteria were included. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated and aggregated using random effects meta-analysis. Results: The results showed that H Conclusions: H

Indexed as

Acute Kidney InjuryAntineoplastic AgentsCisplatinHydrogen SulfideProtective AgentsAnimalsDisease Models, AnimalHumansKidneyOxidative StressAntineoplastic AgentsCisplatinHydrogen SulfideProtective AgentsCisplatin-induced acute kidney injuryExperimental nephrotoxicityHydrogen sulfideVivo studies

Identifiers

PMID40416612
PMCPMC12103845

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.