Evidence map›Paper›PMID 40416611›Full record

ArticlePeerJ2025

Selected Alu methylation levels in the gastric carcinogenesis cascade.

Jiraroch Meevassana, Chawisa Wanda Vongsuly, Tanchanok Nakbua, Supitcha Kamolratanakul, Pichaya Thitiwanichpiwong, Fardeela Bin-Alee, Somboon Keelawat, Nakarin Kitkumthorn

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Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jiraroch MeevassanaCenter of Excellence in Burn and Wound Care, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chawisa Wanda VongsulyCenter of Excellence in Burn and Wound Care, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tanchanok NakbuaCenter of Excellence in Burn and Wound Care, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Supitcha KamolratanakulDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pichaya ThitiwanichpiwongDigital Pathology Center, Siriraj Piyamaharajkarun Hospital, Mahidol University, Bangkok, Thailand.
Fardeela Bin-AleeFaculty of Medicine, Princess of Naradhiwas University, Narathiwat, Thailand.
Somboon KeelawatDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Nakarin KitkumthornDepartment of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Genome-wide hypomethylation, a common epigenetic change that occurs during cancer development, primarily affects repetitive elements, such as Alu repeats. Consequently, Alu repeats can be used as a surrogate marker of genomic hypomethylation. Methods: In this study, we aimed to investigate the correlation between Alu methylation levels and the multistage course of gastric carcinogenesis. Results: We found that the Alu methylation levels in gastric cancer tissue decreased compared with those in normal gastric tissue, with the change in methylation levels and pattern being most significant between chronic gastritis and intestinal metaplasia. Moreover, Alu methylation levels were not associated with Conclusions: Finally, our sensitivity and specificity analyses suggested that Alu methylation level can be used to distinguish gastric cancer tissue from normal tissue. Thus, Alu methylation level shows promise as biomarker for gastric cancer diagnosis.

Indexed as

Alu ElementsCarcinogenesisDNA MethylationStomach NeoplasmsAdultAgedBiomarkers, TumorEpigenesis, GeneticFemaleGastritisHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedBiomarkers, TumorEpstein–Barr virusGastric cancerHelicobacter pyloriHypomethylation

Identifiers

PMID40416611
PMCPMC12101442

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.