ArticleActa Cardiologica Sinica2025
Serum Fetuin-A Affected by Nutritional Status as a Novel Biomarker for Coronary Artery Disease.
Article in Acta Cardiologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- From Adipose Dysfunction to Multi-Organ Steatosis: Defining the Metabolic Steatotic Axis.Current issues in molecular biology · 2026Review
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5 authors.
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Abstract
Background: The mechanisms underlying coronary artery disease (CAD), which is characterized by atherosclerotic plaque accumulation in the arteries, are still not fully understood. The role of serum fetuin-A level in the development of CAD and its effects on other risk factors are important research topics that have attracted increasing attention. The aim of this study was to evaluate serum fetuin-A level and the effects of nutritional status on serum fetuin-A concentration in CAD patients. Methods: The study was carried out on 47 male participants (case group) who were newly diagnosed with CAD by conventional coronary angiography and 40 male participants without CAD (control group) aged between 35-75 years. Biochemical parameters, anthropometric measurements and three-day food records of all participants were recorded. In addition, Gensini and SYNTAX scores were calculated using angiography images to determine the extent and severity of CAD. Results: Serum fetuin-A concentration in the case group was higher than that in the control group (p < 0.001). Waist circumference, hip circumference, waist/height ratio, Gensini and SYNTAX scores and serum fetuin-A levels in the participants in the case group were positively correlated (p < 0.05). In addition, there were negative correlations between serum fetuin-A concentration and dietary polyunsaturated fatty acids, omega-6 fatty acids, vitamin E, vitamin B Conclusions: The results of the study indicate that high serum fetuin-A levels may be a risk factor for the development of CAD, and that nutritional status might affect serum fetuin-A level.
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