ArticleJBMR plus2025
A three-material model for dual-layer detector spectral computed tomography measurements of marrow adipose tissue and bone mineral density.
Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- An evaluation of dual-layer detector spectral CT for the estimation of MRI proton density fat fraction of the liver.Quantitative imaging in medicine and surgery · 2026Article
- Toward next-generation hip implants: From failure mechanisms to translational design.Journal of orthopaedic translation · 2026Review
- Comparison of bone mineral density quantification in dogs using spectral detector computed tomography versus phantom-based conventional computed tomography.Frontiers in veterinary science · 2025Article
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Authors and funding
14 authors.
Funding
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Abstract
Single-energy QCT (SEQCT) scans to measure volumetric BMD (vBMD) are susceptible to errors caused by variability in the amount of marrow adipose tissue (MAT). We developed a three-material model that uses dual-layer spectral CT (DLCT) technology to measure bone matrix (BM), yellow marrow (YM), and red marrow (RM) and compared the results with measurements of proton density fat fraction (PDFF) by MRI and vBMD by SEQCT. Hounsfield units (HU) were measured in the L1-3 vertebrae on 50 and 150 keV mono-energy images in a training set of 100 Chinese adults. The densities of YM and RM in the three-material model were adjusted so that the mean and SD of the YM volume as a fraction of total marrow volume matched historical bone histology data. A validation set of 125 adults was scanned, and the findings were compared with measurements of L1-3 MRI PDFF and SEQCT vBMD. We evaluated the sensitivity, specificity, and area under the ROC curve (AUROC) for DLCT vBMD measurements to predict osteoporosis and investigated the relationship between SEQCT vBMD, DLCT vBMD, and YM volume fraction. The mean (range) of the YM volume as a fraction of total marrow volume averaged 0.471 (0.190-0.674) and 0.480 (0.258-0.760) in men and women. The corresponding results for MRI PDFF were 0.487 (0.224-0.675) and 0.477 (0.238-0.745). The coefficient of determination was
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