ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025
The Prognostic Significance of Serum Uric Acid in Sepsis: A Comparative Study on Adult Patients.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07332637 (Evaluation of the Relationship Between 0-24-Hour Fraction of Inspired Oxygen), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Relationship Between 0-24-Hour Fraction of Inspired Oxygen (FiO₂) Exposure and Changes in the Uric Acid/Albumin Ratio in Intensive Care Unit Patients Diagnosed With Sepsis
Who cites it
2 citing papers in PubMed.
- Accurate prediction of mortality in children with sepsis: development and validation of an explainable model based on real-world data.Italian journal of pediatrics · 2026Article
- Serum Uric Acid in Sepsis: A Hidden Prognostic Clue or Just Another Red Herring?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Sepsis is an oxidative state characterized by a dysregulated immune response to infection, causing multiorgan dysfunction. Uric acid, with its dual role in oxidation and antioxidation, may influence sepsis severity and outcomes. This study aimed to investigate the association between hyperuricemia and the severity and clinical outcomes in sepsis patients. Patients and methods: A prospective, observational cohort study was conducted in medical intensive care units (ICUs) from February 2023 to May 2024. A total of 224 patients aged ≥18 years with clinical suspicion of sepsis and sequential organ failure assessment (SOFA) score ≥2 on admission were enrolled. The patients were divided into hyperuricemic (serum uric acid ≥7 mg/dL) and normouricemic groups. Results: One hundred and twelve patients were enrolled in each group. The hyperuricemic group had significantly higher SOFA (7 vs 5, Conclusion: Hyperuricemia is associated with increased severity of illness and a higher incidence of AKI, prolonged ICU stays, and increased mortality in sepsis. How to cite this article: Katakam SN, Cherukuri M, Kada M, Hanji P, Kudru CU. The Prognostic Significance of Serum Uric Acid in Sepsis: A Comparative Study on Adult Patients. Indian J Crit Care Med 2025;29(5):407-412.
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