ArticleIndian journal of endocrinology and metabolism
Relevance of Polymorphism of Glutathione S-Transferase Genes (GSTM1 and GSTT1) in Diabetic Retinopathy and Diabetic Nephropathy.
Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The causative factors of diabetic retinopathy and nephropathy are genetic as well as environmental. The Glutathione S-transferase gene family is involved in redox balance to reduce oxidative stress, which is an important factor associated with these major diabetic complications. The objective of this study was to investigate the association between the polymorphism of glutathione S-transferase genes (GSTM1 and GSTT1) and type 2 diabetes mellitus (T2DM) patients with diabetic retinopathy (DR) and diabetic nephropathy (DN). Methods: In this cross-sectional study, GSTM1 and GST1 gene polymorphisms were studied in T2DM patients with three groups of 125 cases each: the 1 Results: Compared to the DM group, in the DR group, the GSTT1 null and GSTM1 null genotypes were more prevalent and showed 2.68-folds (OR = 2.68; 95% CI = 1.60-4.48; Conclusion: The significant association between null genotypes of both GSTT1 and GSTM1 with DR and only the GSTM1 null genotype with DN suggests their roles as risk factors.
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