Evidence map›Paper›PMID 40416295›Full record

ArticleCureus2025

Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion (MERS) in an Adult Following Influenza A Infection.

Ahmed Malik, Sadia Sultana Chandni, Ramla Warsame, Ruju Smirtha Thillai, Uday Gollapinni

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmed MalikAcute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke on Trent, GBR.
Sadia Sultana ChandniAcute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke on Trent, GBR.
Ramla WarsameAcute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke on Trent, GBR.
Ruju Smirtha ThillaiAcute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke on Trent, GBR.
Uday GollapinniAcute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke on Trent, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare clinical-radiological entity predominantly reported in pediatric populations, with limited cases in adults. We present a case of a 27-year-old female who developed transient neurological deficits following influenza A infection. She presented with severe headache, neck stiffness, and limb weakness with sensory deficits. Initial suspicion of meningoencephalitis prompted treatment with intravenous antibiotics and antivirals. However, an MRI revealed a hyperintense splenial lesion in the corpus callosum (SCC), supporting a diagnosis of MERS. The patient achieved full recovery without corticosteroids, reinforcing the self-limiting nature of this condition. This case highlights the diagnostic challenges, imaging findings, and management considerations of MERS, underscoring the importance of clinical awareness to avoid unnecessary interventions in adult cases.

Indexed as

corpus callosumcytokine injuryinfluenza amersmrineurological deficitssplenial lesionviral encephalopathy

Identifiers

PMID40416295
PMCPMC12100671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.