Evidence map›Paper›PMID 40416287›Full record

ReviewCureus2025

Skin Manifestations Among Individuals With Hepatitis C Infection.

Erjola Toska, Cameron Minars, Suzanne I Riskin

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erjola ToskaDepartment of Foundational Sciences, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.
Cameron MinarsDepartment of Foundational Sciences, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.
Suzanne I RiskinDepartment of Foundational Sciences, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C, an infection of the liver caused by the hepatitis C virus (HCV), is a growing global health concern, with an increasing annual incidence of primary disease and a notable likelihood of developing extrahepatic manifestations, including dermatological conditions. Studies have explored the relationship between hepatitis C infection and dermatologic manifestations, but there has been a limited number of comprehensive review manuscripts. This review aims to provide a comprehensive summary of studies conducted over a 10-year period, highlighting the relationship between hepatitis C infection and associated skin disorders. For this literature review, four databases, PubMed (NLM), EMBASE, CINAHL, and Web of Science (Core Collection), were searched for peer-reviewed articles written in English, involving human subjects, and published between 2013 and 2023. The search terms used were "(hepatitis C" OR "HCV") AND ("skin" OR "cutaneous" OR "lichen planus" OR "cryoglobulinemia vasculitis" OR "porphyria cutanea tarda" OR "pruritus" OR "spider angiomas")". After removing duplicate articles from the four databases, the remaining articles were assessed for inclusion eligibility. A summary of findings revealed that individuals with hepatitis C exhibit a higher overall incidence of skin infections and experience these infections with increased severity in comparison to individuals without hepatitis C. Patients with hepatitis C face an increased risk of developing conditions such as psoriasis, onychomycosis, cutaneous lupus erythematosus, and lichen planus (LP). In addition, hepatitis C has been shown to be variably associated with oral lichen planus (OLP), suggesting the possibility of genotypic variations in HCV. Furthermore, hepatitis C has been identified as an etiological factor for cryoglobulinemia vasculitis, which manifests with skin symptomatology. These manifestations include palpable purpura, petechiae, vesicles, nodules, and livedo reticularis, predominantly affecting the lower extremities. This comprehensive review aims to provide insight into the association between hepatitis C infection and dermatological manifestations and to explore the presence and implications of skin conditions associated with the infection.

Indexed as

cryoglobulinemia vasculitiscutaneousextrahepatic symptomshcvhepatitis clichen planusmixed cryoglobulinemiaporphyria cutanea tardapruritusskin

Identifiers

PMID40416287
PMCPMC12103101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.