ReviewCureus2025
Potential Applications of Calcium Pyrophosphate for Bone Regeneration: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Fabrication and characterization of biodegradable Zn-Ni spinel ferrite/ β-TCP composite ceramics exhibiting enhanced cell colonization.Journal of materials science. Materials in medicine · 2026Article
- Nanoporous Materials in Biomedical Research: Progress and Potential.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium pyrophosphate (CPP) is a type of calcium phosphate bioceramic and an important intermediate in biological mineralization. It is biocompatible, non-toxic, and osteoconductive, which makes it an attractive material for biomedical applications. Synthetic beta calcium pyrophosphate (β-CPP), used for biomedical applications, is usually obtained by the heat treatment of orthophosphates with a molar ratio of calcium/phosphate (Ca/P)=1. This systematic review aims to investigate the application of CPP for bone regeneration. The research included in vivo studies conducted in this field over the past 50 years. An advanced search was performed using the PubMed, Web of Science, and Scopus databases, and the PRISMA guidelines were followed. Numerous preclinical animal trials have been conducted over the past 50 years to evaluate the use of CPP in the form of granules or porous scaffolds. The study models used were rabbits, dogs, and rats. It was suggested that β-CPP is a biocompatible, absorbable, and osteoconductive material that can be a good alternative to hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP). The published results are promising but insufficient and do not allow for drawing a definitive conclusion on whether CPP can be used as an alternative to HA and β-TCP in bone regenerative therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.